Alternative Treatments

• Alternatives to Interferon

 

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Hepatitis C Interferon Treatment
... Continued

REFERENCES
 

TREATMENT OF CHRONIC HEPATITIS C
Standard Therapy 
Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic non-A, non-B  hepatitis with recombinant human alpha interferon: A preliminary report. New  Engl J Med 1986; 315:1575-1578.
Davis GL, Balart LA, Schiff ER, et al. Treatment of chronic hepatitis C with  recombinant interferon alpha: A multicenter randomized, controlled trial. New  Engl J Med 1989; 321:1501-1506.
Marcellin P, Boyer N, Giostra, et al. Recombinant human alpha- interferon in  patients with chronic non A non B hepatitis: a multicenter randomized controlled  trial from France. Hepatology 1991; 13:393-397.
Causse x, Godinot H, Ouzan D, et al. Comparison of 1 or 3 MU of interferon  alfa-2b and placebo in patients with chronic non-A non-B hepatitis.  Gastroenterology 1991; 101:497-502.
TinĊ½ F, Margin S, Craxi A, Pagliaro L. Interferon for non-A, non- B chronic  Hepatitis: a meta-analysis of randomized clinical trials. J Hepatol 1991;  13:192-199.

 
Alternative regimens: Higher dose, Longer duration
Beloqui O, Prieto J, Suarez M, Gil B, Qian CH, Garcia N, Civeira MP.  N-acetyl cysteine enhances the response to interferon-alpha in chronic hepatitis  C: a pilot study. J Interferon Res 1993; 13:279-282.
Kakumu S, Yoshioka K, Wakita T, Ishikawa T, Takayanagi M, Higashi Y. A pilot  study of ribavirin and interferon beta for the treatment of chronic hepatitis C.  Gastroenterology 1993; 105:507- 512.
Liaw YF, Sheen IS, Lin SM, Chen TJ, Chu CM. Effects of prednisolone  pretreatment in interferon alfa therapy for patients with chronic non-A, non-B  (C) hepatitis. Liver 1993; 13:46-50.
 
Alternatives to Interferon
Camps J, Garcia N, Riezu-Boj JI, Civiera MP, Prieto J. Ribavirin in the  treatment of chronic hepatitis C unresponsive to alfa interferon. J Hepatol  1993; 19:408-412.
Bodenheimer HC, Lindsay K, Davis GL, et al. Ribavirin treatment of chronic  hepatitis C. Hepatology 1994; 20:(abstract in press).
 
SPECIAL PATIENT GROUPS
Decompensated Cirrhosis
Dimopoulou M, Fafoutis K, Basiliou K, Ketikoglou J, Karvountzis G.  Interferon alfa-2a for decompensated liver disease caused by wither chronic  hepatitis B or C: preliminary results of a pilot study. Gut 1993; 34 (suppl  2):S104-105.
 
HIV infected patients
Eyster ME, Diamondstone LS, Lien JM, Ehmann WC, Quan S, Goedert JJ. The  natural history of hepatitis C virus infection in multitransfused hemophiliacs:  Effects of coinfection with human immunodeficiency virus. Acquir Immune Defic  Syndr 1993; 6:602.
Eyster ME, Fried MW, DiBisceglie AM, Goedert JJ. Increasing HCV RNA levels  in hemophiliacs: Relationship to HIV infection and liver disease. Blood 1994;  (in press).
Boyer N, Marcellin P. Degott C, Degos F, Saimot AG, Erlinger S, Benhamou JP.  Recombinant interferon-alpha for chronic hepatitis C in patients positive for  antibody to human immunodeficiency virus. J Infect Dis 1992; 165:723-726.
 
Hemophiliacs
Makis M, Preston FR, Triger DR, Underwood JC, Westlake L, Adelman MI. A  randomized controlled trial of recombinant interferon-alpha in chronic hepatitis  C in hemophiliacs. Blood 1991; 78:1672-1677.
 
Transplant Recipients
Lim HL, Lau GK, Davis GL, Dolson DJ, Lau JYN. Cholestatic hepatitis leading  to hepatic failure in a patients with organ- transmitted hepatitis C virus  infection. Gastroenterology 1994; 106:248-251.
Ferrel LD, Wright TL, Roberts J, Ascher N, Lake J. Hepatitis C viral  infection in liver transplant recipients. Hepatology 1992; 16:865-876.
Wright HI, Gavaler JS, Van Thiel DH. Preliminary experience with alpha-2b  interferon therapy of viral hepatitis in liver allograft recipients.  Transplantation 1992; 53:121-124.
 
Asymptomatic Carriers
Naito M, Hayashi N, Hagiwara H, Hiram N, Kasahara A, Fusamato H, Kamada T. Serum  hepatitis C virus RNA quantity and histological features of hepatitis C virus  carriers with persistently normal ALT levels. Hepatology 1994; 19:871-875.
 
Extrahepatic Disease
Lunel F, Musset L, Cacoub P, et al. Cryoglobulinemia in chronic liver diseases:  role of hepatitis C virus and liver damage. Gastroenterology 1994;  106:1291-1300.
 
TREATMENT OF ACUTE HEPATITIS C
Viladomiu L, Genesca J, Estaban JI, et al. Interferon alpha in acute  posttransfusion hepatitis C: a randomized controlled trial. Hepatology 1992;  15:767-769.
Omata M, Yokosuka O, Takano S et al. Resolution of acute hepatitis C after  therapy with natural beta interferon. Lancet 1991; 338:914-915.
Lampertico P, Rumi M, Romeo R, Craxi A, Soffrededini R, Biassoni D, Colombo  M. A multicenter randomized controlled trial of recombinant interferon alpha-2b  in patients with acute transfusion- associated hepatitis C. Hepatology 1994;  19:19-22.
Tassopoulos NC, Koutelou MG, Papatheodoridis G, et al. Recombinant human  interferon alfa-2b treatment for acute non-A, non-B hepatitis. Gut 1993;  34:S130-132.
 

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